CUDC-101是組蛋白去乙?；傅亩喟悬c抑制劑。它被設(shè)計成直接抑制表皮生長因子受體(EGFR)和HER2以及I類和II類HDACs。已經(jīng)表明，CUDC-101能夠在體外和體內(nèi)異種移植物模型中有效地抑制多種腫瘤類型的發(fā)展，包括拉帕替尼-和埃羅替尼-抗性癌細胞系。機制研究提供了證據(jù)，表明CUDC-101不僅直接抑制EGFR和HER2信號，而且間接減弱存活信號通路Akt、HER3和MET。

產(chǎn)品性質(zhì)：

Cas No.:1012054-59-9

別名:7-[[4-(3-乙炔基苯基氨基)-7-甲氧基喹唑啉-6-基]氧基]-N-羥基庚酰胺,CUDC101, CUDC 101

化學(xué)名:7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide

Canonical SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO

分子式:C24H26N4O4

分子量:434.49

溶解度:≥ 21.7 mg/mL in DMSO

儲存條件:Store at -20°C

注意事項：

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Reference:

[1].Cheng-Jung Lai, Rudi Bao, Xu Tao, Jing Wang, Ruzanna Atoyan, Hui Qu, Da-Gong Wang, Ling Yin, Maria Samson, Jeffrey Forrester, Brian Zifcak, Guang-Xin Xu, Steven DellaRocca, Hai-Xiao Zhai, Xiong Cai, William E. Munger, Mitchell Keegan, Carmen V. Pepicelli, and Changgeng Qian. CUDC-101, a Multitargeted Inhibitor of Histone Deacetylase, Epidermal Growth Factor Receptor, and Human Epidermal Growth Factor Receptor 2, Exerts Potent Anticancer Activity. Cancer Res May 1, 2010 70; 3647.